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Item Information   Holdings       More by this author     Daley, Kevin     Subjects     Embolism, AIr -- prevention & control     Cardiopulmonary bypass -- Adverse effects     Suction -- adverse effects     Vacuum     Veins     MSP Thesis.     Browse Catalog     by author:      Daley, Kevin       by title:      The effect of vacuum...         MARC Display

The effect of vacuum assisted venous drainage and venous reservoir level on microbubble persistence into the arterial line / Kevin Daley. by Daley, Kevin Subjects Embolism, AIr -- prevention & control   Cardiopulmonary bypass -- Adverse effects   Suction -- adverse effects   Vacuum   Veins   MSP Thesis. Description:  46 leaves : ill. ; 29 cm. Contents:  Thesis advisor: Dr. Ronald Gerrits Committee members: Dr. Larry Fennigkoh, Matthew Hietpas Introduction -- Background -- Methods and materials -- Results -- Discussion -- Conclusion -- A: Raw data -- B: Data separated by bubble size Gaseous microemboli (GME) have been shown to be contributing factors of neurological dysfunction following cardiopulmonary bypass (CPB). Air can enter the CPB circuit from a number of sources; the most common site is the venous cannulation site. As air travels down the venous lines and into the venous reservoir, large bubbles are broken up to small GME that have the potential to persist to the arterial line and ultimately to the patient. Two factors that are thought to contribute to the number of GME persisting into the arterial line are the degree of negative pressure used with vacuum assisted venous drainage (VAVD) and the volume of fluid in the venous reservoir. Although both of these have been studied to some extent, there are no published studies that combine the effects of both on persistent GME. This study was designed to test the combined effects of VAVD and venous reservoir volume on the number of bubbles that escape from a hard-shell venous reservoir. An in vitro CPB circuit was constructed to test the persistence of GME following a 1mL injection of air into the "venous line" of the circuit. The circuit was tested at five levels of vacuum pressure in combination with three levels of venous reservoir volume. The number and volume of GME escaping from the venous reservoir were measured using the Emboli Detection and Classification (EDAC) quantifier (Luna Innovations). The results of this study show that there are significantly more bubbles that escape from the venous reservoir under conditions of high levels of vacuum pressure (-40mmHg and -80mmHg). They also show that high levels of reservoir volume (2000mL) allow significantly fewer bubbles to persist into the arterial line.   Copy/Holding information Location Collection Call No. Status   Walter Schroeder Library Master's Theses AC805 .D35 2010 Available Add Copy to MyList Format: HTMLPlain textDelimited Subject:   Email to:

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