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Item Information   Holdings       More by this author     Bell, Angela     Subjects     Cardiopulmonary bypass -- Adverse effects     Hemostasis     Blood Platelets     Blood Coagulation.     MSCS Thesis.     Browse Catalog     by author:      Bell, Angela       by title:      Evaluation of platel...         MARC Display

Evaluation of platelet function assays : analysis of advantages, disadvantages and limitations in predicting bleeding / Angela Bell. by Bell, Angela Subjects Cardiopulmonary bypass -- Adverse effects   Hemostasis   Blood Platelets   Blood Coagulation.   MSCS Thesis. Description:  152 leaves : ill. ; 29 cm. Contents:  Thesis advisor: Dr. Ronald Gerrits. Committee members: Dr. John Gassert, Dr. Jeffrey LaMack. Introduction -- Background -- Primary Hemostasis -- Cardiopulmonary bypass and platelet/hemostatic dysfunction -- Assessment of platelet function -- Conclusion -- Recommendations -- References. Clinicians, perfusionists, and all those involved in cardiopulmonary bypass and hemostatic management rely on platelet function assays to make clinical decisions. Such decisions might include the administration of pharmaceuticals or the use of various blood products -- each of which has its own costs and risks associated with it. Therefore, it is critical that the data provided by the platelet function assays are accurate and used within the correct context. A brief review of the literature indicates that clinical decisions seldom take into account the shortcomings associated with the various platelet function tests in use, particularly the associated lack of sensitivity and specificity. Clinicians use the results from these tests to guide hemostatic management despite a lack of evidence supporting their use in this manner. This project was designed to investigate several platelet function assays currently on the market including their advantages, disadvantages, and most appropriate uses. It found that everything from the anticoagulant used to the method of collection may have a profound effect on the platelet function tests. This project summarizes the important considerations of each of the platelet function tests and provides recommendations for which assays to use in various situations. This project provides students, clinicians, and perfusionists with a concise guide to many platelet function assays currently available for use in hemostatic management and when they can be used effectively.   Copy/Holding information Location Collection Call No. Status   Walter Schroeder Library Master's Theses AC805 .B44 2009 Available Add Copy to MyList Format: HTMLPlain textDelimited Subject:   Email to:

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