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Clinical impact of del Nido versus Custodiol HTK cardioplegia solutions in the postoperative period in pediatric cardiac surgery patients : a thesis submitted to the faculty of the Milwaukee School of Engineering in partial fulfillment of the requirements for the degree of Master of Science in Perfusion / by John Pawlak.

by Pawlak, John, author., Gerrits, Dr. Ronald, thesis advisor , Varner, Caleb, committee member , Shimek, Gary , Milwaukee School of Engineering

[Milwaukee School of Engineering], [2018]

Pediatric cardiology

Cardiac arrest, Induced

Cardiopulmonary bypass

Isolation perfusion (Physiology)

leaves : illustrations, some of which are in color ; 29 cm

Introduction -- Background -- Methods -- Results -- Discussion -- Conclusions -- References -- Appendix A: Del Nido data -- Appendix B: HTK data.

Del Nido and Custodiol Histidine-Tryptophan-Ketogluterate (HTK) are common solutions employed during pediatric heart surgry. They differ in their mechanism of cardiac arrest; del Nido causes a depolarizing arrest and HTK a hyperpolarizing arrest. While both of these solutions have been evaluated for their impact on patient outcomes independently, limited research exists comparing them directly. This study retrospectively compared patient outcomes between two groups of patients based on which cardioplegia solution was used. Patients were grouped by del Nido (n=30) or Custodiol HTK (n=30) and stratified by STAT score. T-tests using MiniTab 18 statistical software were performed between del Nido and Custodiol Groups for each parameter at each STAT level. Compared variables included duration of mechanical ventilation, total length of hospital stay, and change in systemic ventricle ejection fraction. No statistical difference was observed between clinical outcomes on the parameters measured between the cardioplegia solutions used at any STAT level. Multiple studies have compared Custodiol and del Nido to conventional cold blood cardioplegia, but few compare them directly. Previous studies have found no significant difference between del Nido and Custodiol when studies compared to cold blood cardioplegia. It stands to reason when compared directly, no significant difference would be found between del Nido and Custodiol. The results of this study are consistent with previous findings. Both solutions are viable choices for myocardial protection in pediatric heart surgery.

https://msoe.tind.io/record/947

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