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Item Information   Holdings       More by this author     Riddle, Emily V.     Subjects     Blood -- Transfusion     Blood Transfusion -- adverse effects.     Postoperative care     Intraoperative Care.     Preoperative care     MSCS Thesis.     Browse Catalog     by author:      Riddle, Emily V.       by title:      A retrospective stud...         MARC Display

A retrospective study of patient outcomes following transfusions with either fresh or aged packed red blood cells / Emily V. Riddle. by Riddle, Emily V. Subjects Blood -- Transfusion   Blood Transfusion -- adverse effects.   Postoperative care   Intraoperative Care.   Preoperative care   MSCS Thesis. Description:  107 leaves : ill. ; 29 cm. Contents:  Thesis advisor: Dr. Ronald Gerrits. Committee members: Dr. Larry Fennigkoh, Dr. Charles Tritt. Introduction -- Background -- Hypothesis -- Methods -- Results -- Appendix A: Chi-square test: Fischer's exact test of postoperative complications -- B: Analysis of variance testing of co-morbidities -- C: Variables of stepwise binary logistic regression. The argument of when to transfuse a patient has been, and still is, a controversial issue in operating rooms around the country. Over the past few decades much research has focused on problems that are associated with transfusions. These problems included the chance of disease transmission and transfusion reactions which were associated with human-error during blood typing. More recently, it has been noted that postoperative complication risk rises with the use of packed red blood cells (pRBCs). Some of this research has focused on the complications associated with the age of transfused pRBCs. Several studies have noted the changes that occur within the storage lesion can increase mortality rates, length of hospital stay, renal and pulmonary insufficiency and infection rates. This thesis focused on performing a retrospective study to investigate how the age of pRBCs correlated with postoperative complications. The study used data from coronary artery bypass grafting (CABG) patients at Saint Luke's Medical Center in Milwaukee, Wisconsin. The age of pRBCs administered were compared to various postoperative complications. This study also involved determining which risk factors were the best predictors of postoperative pulmonary insufficiency, postoperative renal failure, mortality and cardiac arrest. Results indicated that the addition of pRBCs >= 14 days old increased a patient's risk of developing pulmonary insufficiency by 2.3 times. It was also found that the addition of pRBCs>= 14 days old also increased a patient's risk of developing renal failure, mortality, and cardiac arrest by 5.6 times. Outcomes from this research show that there is increased risk associated with the administration of older pRBCs; however, because the population size was small, stronger associations between the age of pRBCs transfused and postoperative complications could not be made.   Copy/Holding information Location Collection Call No. Status   Walter Schroeder Library Master's Theses AC805 .R51 2007 Available Add Copy to MyList Format: HTMLPlain textDelimited Subject:   Email to:

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