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Item Information   Holdings       More by this author     Cook, Damien M.     Subjects     Blood -- Viscosity     Biological control systems -- Mathematical models.     Cardiac arrest, Induced     Cardiopulmonary bypass -- Adverse effects     MATLAB     MSP Thesis.     Browse Catalog     by author:      Cook, Damien M.       by title:      Effects of viscosity...         MARC Display

Effects of viscosity on cardioplegia blood flow as determined by a mathematical model incorporating elastic coronary arteries / by Damien M. Cook. by Cook, Damien M. Subjects Blood -- Viscosity   Biological control systems -- Mathematical models.   Cardiac arrest, Induced   Cardiopulmonary bypass -- Adverse effects   MATLAB   MSP Thesis. Description:  71 leaves : figures, 29 cm. Contents:  List of figures -- Introduction -- Background -- Materials and methods -- Results -- Discussion -- Conclusion -- Future topics of research -- References -- Appendices. Cardioplegia is the solution used to arrest the heart during nearly all types of cardiac surgeries. Yet, in spite of this widespread use, the techniques of cardioplegia vary in solution, temperature, and mode of delivery. This paper reviews important issues to consider regarding myocardial protection, including ischemia, reperfusion injury, electrophysiology of the action potential and cardioplegia, as well as the effects of temperature and hematocrit on cardioplegia. One consideration of cardioplegia that has not been well described is how viscosity changes affect the distribution of cardioplegia in the coronary vasculature. Changes in cardioplegia composition and temperature change its viscosity. This in turn would be expected to change the flow (or pressure) and possible the distribution of the cardioplegia throughout the heart. This paper describes a mathematical model developed to predict the distrubition of steady flow through a network of elastic tubes. With constant pressures, it is expected that the flow of cardioplegia would be greater with a less viscous solution. Also, at any given level of stenosis, the relative flow through a coronary stenosis would be greater with the less viscous cardioplegia. The computer software program MATLAB was used to develop and simulate the model. This model was then used to study the relative flows of cardioplegia throughout the left coronary arterial system. The model was run under conditions of set flow as well as with a set source pressure to evaluate the relative flow distribution of an unobstructed artery system. Then, a coronary stenosis was simulated in the left anterior descending artery, and the relative flow was evaluated with respect to the percent of stenosis. These conditions were evaluated for viscosities corresponding to blood, 4:1, and crystalloid cardioplegia. The model results revealed that with a less viscous solution, cardioplegic flows must be increased to maintin a source pressure of 50 mmHg. Also, changes in the viscosity of the medium produced a near linear effect in respect to the relative flow through a stenotic lesion. This was not expected in the nonlinear equation of flow described in the model.   Copy/Holding information Location Collection Call No. Status   Walter Schroeder Library Master's Theses AC805 .C66 2004 Available Add Copy to MyList Format: HTMLPlain textDelimited Subject:   Email to:

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