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Item Information   Holdings       More by this author     Baternik, Aaron     Subjects     Cardiopulmonary bypass -- Adverse effects     Hypothermia     Fever     Extracorporeal Circulation -- methods     Monitoring, Physiologic     MSP Thesis.     Browse Catalog     by author:      Baternik, Aaron       by title:      The effect of patien...         MARC Display

The effect of patient variables on the rewarming rate during cardiopulmonary bypass / by Aaron Baternik. by Baternik, Aaron Subjects Cardiopulmonary bypass -- Adverse effects   Hypothermia   Fever   Extracorporeal Circulation -- methods   Monitoring, Physiologic   MSP Thesis. Description:  100 leaves : ill. ; 29 cm. Contents:  Advisor: Dr. Larry Fennigkoh. Committee Members: Matthew Hietpas, Dr. Charles Tritt. Background -- Hypothesis -- Materials and methods -- Results -- Discussion -- Conclusion -- References -- Appendix A ) Trend plots of area -- B) Correlation matrix -- C) Scatter plots of data -- D) Raw data During cardiopulmonary bypass (CPB), hypothermia is commonly used to decrease methbolism and the tissue's need for oxygen. At the end of the procedure, the patient is rewarmed to their normal body temperature. This author could find no previous studies that aimed to determine how or why patients may rewarm at different rates. This study attempts to determine which patient variables (i.e. age, gender, diabetes, body mass index (BMI), body surface area (BSA)) affect the rewarming rate during CPB). Hypothesis: Patients having the following attributes will rewarm at a slower rate (measures in 0C/min): advanced age, male, non-diabetic, high BMI, and large BSA. Conversely, younger patients, females, diabetics, patients with a low BMI, and patients with a small BSA will rewarm at a faster rate on cardiopulmonary bypass. Sixteen patients participated in the study. The average age of the study participants was 68 ± 9 years. Average BSA and BMI were 2.05 ± 0.30m2 and 33.6 ± 11.1 kg/m2, respectively. Six of the patients were female, ten were male, and five of the sixteen were diabetic. Surgeries were performed using standard protocols. The following data were recorded every two minutes: venous blood temperature, arterial blood temperature, water bath temperature, esophageal temperature, core temperature, mean arterial blood pressure, and pump flow rate. A multiple regression was performed using the rewarming rate as the dependent variable. The rates of esophageal and core rewarming were 0.240 ± 0.1150C/min and 0.0670 ± 0.03270C/min, respectively. All other variables were treated as independent. None of the patient variables originally hypothesized to affect rewarming rate were found to have a significant effect on the rewarming rate. None of the proposed independent variables significantly explained differences in the esophageal rewarming rate; R2 = 0.345, the adjusted R2 = 0.181, and all associated p-values were greater than 0.05. Using a backward elimination stepwise regression, the coldest temperature on bypass (coldest T) was correlated with the highest core rewarming rate; R2 = 0.800, adjusted R2 = 0.786, and p < 0.001. The power of this test was found to be 0.99. All other independent variables were eliminated and not found to be significant.   Copy/Holding information Location Collection Call No. Status   Walter Schroeder Library Master's Theses AC805 .B38 2004 Available Add Copy to MyList Format: HTMLPlain textDelimited Subject:   Email to:

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