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Item Information   Holdings       More by this author     Jackson, Darren E.     Subjects     Cardiopulmonary bypass -- Adverse effects     Blood -- Circulation, Artificial     Pulmonary edema.     Hypothermia     MSP Thesis.     Browse Catalog     by author:      Jackson, Darren E.       by title:      Effect of simultaneo...         MARC Display

Effect of simultaneous versus sequential antegrade/retrograde cardioplegia on the percentage of myocardial water content in isolated fetal bovine hearts / by Darren E. Jackson, B.S. by Jackson, Darren E. Subjects Cardiopulmonary bypass -- Adverse effects   Blood -- Circulation, Artificial   Pulmonary edema.   Hypothermia   MSP Thesis. Description:  49 leaves : ill. ; 28 cm. Contents:  Committee chair: Dr. Ronald Gerrits. Committee members: Dr. Charles Tritt, Dr. Larry Fennigkoh. Introduction -- Background -- Hypothesis -- Materials and methods -- Results -- Discussion -- References. Background: Cardiac surgeries that utilize techniques to stop the heart during surgery have been common since about the 1960s. However, there are still numerous instances of cardiac dysfunction following cardiopulmonary bypass. One of the most important factors in this cardiac dysfunction is myocardial edema. Myocardial edema has been shown to decrease systolic cardiac function, decrease cardiac output and impair diastolic function. During cardiac surgery the technique of cardioplegia delivery can have an effect on the formation of myocardial edema. This study tested the hypothesis that simultaneous antegrade/retrograde cardioplegia (SARC) will increase myocardial edema when compared to sequential antograde/retrograde cardioplegia. Methods: Fetal bovine hearts were obtained from Emmpack Foods, Inc. The hearts were separated into two groups, SARC group (n = 14) and sequential cardioplegia group (n = 14). A Quest MPS℗ Myocardia Protection System was utilized to perform the cardioplegia delivery. The SARC group received a total of 1000 mL of Plasmalyte A, while the sequential group received 500 mL antegrade and 500 mL retrograde. Following cardioplegia delivery, the hearts were weighed to estimate the wet tissue weight and dried in a food dehydrator for 24 hours, and weighed to estimate the dry tissue weight. From these tissue weights the percentage of myocardial tissue water content was calculated to estimate myocardial edema. Results: The percentage of myocardial water content (%MCW) (mean +/- standard deviation) was increased in the SARC group (78.15 +/- 2.23) when compared to the sequential cardioplegia group (75.20 =/- 3.62. It was also determined that the weight of the heart had an influence on the %MCW. Discussion: This study indicated that SARC has more influence on the formation of myocardial edema than sequential cardioplegia. This may be due to the increase in intramyocardial tissue pressure when antegrade and retrograde cardioplegia are administered simultaneously. There was also an effect of the weight of the heart on %MCW, which may be explained by the difference in cc/gram of cardioplegia administered between small hearts (5.00 =/- 0.96 cc/gram) and large hearts (3.09 +/- 0.48 cc/gram).   Copy/Holding information Location Collection Call No. Status   Walter Schroeder Library Master's Theses AC805 .J23 2004 Available Add Copy to MyList Format: HTMLPlain textDelimited Subject:   Email to:

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