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Item Information   Holdings       More by this author     Voborsky, Shannon R.     Subjects     Perfusion     Heart, Artificial -- adverse effects     Models, Cardiovascular     Blood -- Circulation, Artificial     Extracorporeal Circulation -- methods     Heart -- Ventricles     MSP Thesis.     Browse Catalog     by author:      Voborsky, Shannon R.       by title:      Assessment of right ...         MARC Display

Assessment of right heart perfusion in the presence of a non-pulsatile left ventricular assist device / Shannon R. Voborsky. by Voborsky, Shannon R. Subjects Perfusion   Heart, Artificial -- adverse effects   Models, Cardiovascular   Blood -- Circulation, Artificial   Extracorporeal Circulation -- methods   Heart -- Ventricles   MSP Thesis. Description:  125 leaves : ill. ; 29 cm. Contents:  Committee members: Dr. Vincent Canino, Dr. Ronald Gerrits, Dr. Lisa Milkowski Introduction -- Background -- Materials and methods -- Results -- Discussion -- Conclusions -- References -- Appendices A) SIMULINK blocks used to build the functional model components - B) Variables used in the complete model: Descriptions, initial settings and units - C) SIMULINK functional model components - D) Complete SIMULINK cardiovascular model with incorporated non-pulsatile left ventricular assist device system - E) MATLAB elastance functions - F) Adjusted variable settings for each of the experimental simulations. Recent focus has been on utilizing ventricular assist devices (VAD's) as destination therapies. To address this possibility, many new centrifugal VAD's have been designed which are less complex mechanically, have fewer moving parts, and are much smaller allowing for easier implantation in comparison to the conventional pulsatile VAD's. This research attempted to determine whether a centrifugal pump, when placed in parallel with a compromised left ventricle, allows for adequate perfusion of the myocardium. Perfusion of the right side of the heart was of particular concern because right heart failure is too often a devastating complication of left ventricular assist device (LVAD) insertion. A mathematical model of the cardiovascular and coronary system from previous research was utilized and revised to accommodate the application of a centrifugal LVAD and to examine the effects of left ventricular contribution and systemic vascular resistance on right coronary artery perfusion. The results suggested that while the LVAD does improve right coronary blood flow, when the left ventricular ejection fraction is 22% or less, the coronary flow becomes substantially less than under normal physiological conditions. In the presence of low systemic vascular resistance (SVR) a centrifugal pump may not be able to produce enough flow to provide adequate aortic pressures, however, in the presence of high SVR, the right coronary artery blood flow increased in comparison to baseline. These results imply that centrifugal LVAD may have a place as an interventionary tool (such as a bridge to recovery or transplant), which, when applied early on in the disease process may avoid right heart failure all together. Its application as a destination therapy may or may not be realized in the future.   Copy/Holding information Location Collection Call No. Status   Walter Schroeder Library Master's Theses AC805 .V63 2003 Available Add Copy to MyList Format: HTMLPlain textDelimited Subject:   Email to:

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