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Item Information   Holdings       More by this author     McNair, Trisha M.     Subjects     Cardiopulmonary bypass -- Adverse effects     Extracorporeal Circulation     Blood -- Circulation, Artificial -- Complications.     Hemostasis, Surgical     Blood Coagulation     MSP Thesis.     Browse Catalog     by author:      McNair, Trisha M.       by title:      The effects of high ...         MARC Display

The effects of high shear stress on platelet function / by Trisha M. McNair. by McNair, Trisha M. Subjects Cardiopulmonary bypass -- Adverse effects   Extracorporeal Circulation   Blood -- Circulation, Artificial -- Complications.   Hemostasis, Surgical   Blood Coagulation   MSP Thesis. Description:  60 leaves ; ill. ; 28 cm. Contents:  Advisor: Dr. Ronald Gerrits. Committee members: Dr. Charles Tritt, Dr. Larry Fennigkoh. Introduction -- Background -- Hypothesis -- Methods and materials -- Results -- Discussion -- References -- Appendices. Platelets play a major role in maintaining hemostasis of the body after all types of insults. They are especially necessary after a major surgical procedure that requires cardiopulmonary bypass. Yet cardiopulmonary bypass has itself been shown to cause platelet dysfunction and destruction through intrinsic and extrinsic mechanisms. One of the reasons for platelet damage may be the shear stress produced within an extracorporeal circuit. When vacuum assisted venous return is implemented into the circuit, there is an even greater shear stress produced which could cause greater trauma to the platelets. The goal of the current study was to evaluate the effect that shear stress caused by vacuum assisted venous drainage has on platelet function. To perform this study a total of 24 experimental trials were performed in which bovine blood was perfused through circuits exhibiting different levels of shear stress. Each trial was run for two hours at a pressure of 0, -15, -30, or -45 with a 30 or 36 French venous cannula. A Plateletworks machine was used to determine platelet function at the initial, one hour, and two hour intervals. Within the first hour of CPB there was a decrease in platelet function compared to the initial reading. There was also a correlation between the level of shear stress and the degree of platelet dysfunction. A decrease in white blood cell count was also found between the initial and two hour time points. The changes that were observed during this experimentation are consistent with past studies and with the known effects that artificial surfaces and shear stresses have on platelets. This is the first study that has attempted to evaluate the effect of high shear stress caused by vacuum assisted venous draining on platelet function. Based on this study it is recommended that further research be performed to determine the effects of increased shear stress on platelets over a greater range of shear stress and within larger groups.   Copy/Holding information Location Collection Call No. Status   Walter Schroeder Library Master's Theses AC805 .M39 2003 Available Add Copy to MyList Format: HTMLPlain textDelimited Subject:   Email to:

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