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Item Information   Holdings       More by this author     Schuck, Michael D.     Subjects     Grignard reagents -- Waste minimization.     Source reduction (Waste management) -- Chemical plants.     Natural attenuation.     MSEV Project.     Browse Catalog     by author:      Schuck, Michael D.       by title:      Waste minimization o...         MARC Display

Waste minimization of a Grignard reagent / by Michael D. Schuck. by Schuck, Michael D. Subjects Grignard reagents -- Waste minimization.   Source reduction (Waste management) -- Chemical plants.   Natural attenuation.   MSEV Project. Description:  58 leaves : ill. ; 28 cm. Contents:  Advisor: Julianne Hunter Introduction and background -- Mettler-Toledo RXE forum literature -- Aldrich Chemical literature -- Methodology -- Review of existing synthesis route -- Determination of variables -- Design and performance of experiments -- Results and discussion -- Economic impact & cost analysis -- Other issues (Future applications) -- Conclusions and recommendations -- References -- Appendix A) RC-1 Experiments B) Waste Reduction Potential Grignard reagents represent a few of the several thousand organic chemicals, which are batch synthesized by Aldrich Chemical Company. Many of the batch synthesis processes are run infrequently and thus have not been optimized for efficiency, yield, environmental compatibility and safety. Often the same process variables (agitator speed, addition rates, etc.) which were found to work during small-scale process development are used in the larger scale production process. Optimizing these processes would increase the efficiency and yield and reduce the generation of waste. This paper will present the reduction of wastes achieved by optimizing the synthesis of a Grignard reagent, vinylmagnesium chloride 1.6 molar solution in tetrahydrofuran. Increasing demand has caused Aldrich to scale-up the batch production of vinylmagnesium chloride to new and larger reactors. The initial scale up of vinylmagnesium chloride to a 100 gallon reactor resulted in a low yield. A project was then undertaken to determine methods of increasing the reaction yield using a RC-1 reaction calorimeter and scale up methods from literature. The RC-1 is an automated lab reactor operating on a liter scale which measures and controls reaction variables such as pH, heating, cooling, stirring, and addition rate(s) [1]. Two factors were found which greatly increased the reaction yield: double reaction initiation with 1,2 dibromoethane and reducing the solvent used (i.e. increasing the reactant concentrations). When applied to the production of vinylmagnesium chloride in a 500 gallon reactor the yield was 82%. Based upon this result it is anticipated that waste solvents will be reduced by 2,100 liters/yr and waste water by 1,604 liters/yr. This same technique can be used to minimize the wastes from production of several dozen other Grignard reagents at Aldrich.   Copy/Holding information Location Collection Call No. Status   Walter Schroeder Library Master's Theses AC805 .S377 2001 Available Add Copy to MyList Format: HTMLPlain textDelimited Subject:   Email to:

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