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Item Information   Holdings       More by this author     Moaref, Kourosh.     Subjects     Blood -- Circulation, Artificial     Extracorporeal Circulation -- methods     Heart -- Left ventricle     MSP Thesis.     Browse Catalog     by author:      Moaref, Kourosh.       by title:      Modeling of coronary...         MARC Display

Modeling of coronary perfusion in the presence of a left ventricular assist device / by Kourosh Moaref. by Moaref, Kourosh. Subjects Blood -- Circulation, Artificial   Extracorporeal Circulation -- methods   Heart -- Left ventricle   MSP Thesis. Description:  iii, 146 leaves : ill. ; 28 cm. Contents:  Committee members: Dr. Vincent Canino, Dr. John Gassert, Dr. Ronald Gerrits Introduction -- Background -- Coronary perfusion -- Model development -- Model testing and simulation -- Simulation results of circulatory assisted coronary perfusion -- Discussion and conclusion -- Comments and paths for future research -- Bibliography -- Appendices -- A- Complete model listing B- Elastance functions C- LVAD ejection delay & coronary flow D- LV elastance & coronary flow E- Heart rate & coronary flow -- Simulink block descriptions. Left ventricular assist devices have long been utilized in patients with endstage heart failure awaiting cardiac transplantation. Their purpose, in this application, has been to sustain and improve the function of the patient's other vital organs until such a time when a donor heart becomes available. However, recent advances in LVAD technology and reliability has sparked a new interest in the use of these devices as a bridge of myocardial recovery. To this end, a closed loop model of the circulatory system was developed to study the effect of left ventricular assist devices on coronary perfusion. The effect of LVAD ejection delay, heart rate, and LV elastance on coronary blood flow and outflow may be achieved if the LVAD ejection delay is synchronized at a 0.3 to 0.5 second delay after cardiac contraction. The simulation results suggest that increasing heart rate reduces coronary blood flow. Finally, the relationship between cardiac elastance and coronary perfusion was examined and the simulation results suggest that coronary blood flow increases with increasing elastance, suggesting that a diseased myocardium may benefit more from an earlier LVAD implantation.   Copy/Holding information Location Collection Call No. Status   Walter Schroeder Library Master's Theses AC805 .M63 2000 Available Add Copy to MyList Format: HTMLPlain textDelimited Subject:   Email to:

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