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Item Information   Holdings       More by this author     Webb, David P.     Subjects     Blood -- Transfusion, Autologous     Inflammation     Cardiopulmonary bypass -- Adverse effects     MSP Thesis.     Browse Catalog     by author:      Webb, David P.       by title:      Pulmonary implicatio...         MARC Display

Pulmonary implications of filtering various mediators of morbidity found in salvaged blood / by David P. Webb. by Webb, David P. Subjects Blood -- Transfusion, Autologous   Inflammation   Cardiopulmonary bypass -- Adverse effects   MSP Thesis. Description:  v, 42 leaves : ill. ; 29 cm. Contents:  Committee members: Dr. Charles Tritt, Charles Altenburn, Francis Downey, M.D., Daniel Maribel, M.D. Introduction -- Materials and methods -- Results -- Discussion -- Recommendations -- Appendix A: Instructions for authors - B: Efficacy of salvaged blood reinfusion on circulating red cells - C: Effect of filtration on pulmonary shunt fraction - D: Effect of filtration on pulmonary vascular resistance - E: Effect of filtration on oxygen index - F: Change in oxygen index following salvaged blood reinfusion - G: Effect of filtration on arterial-venous oxygen difference - H: Effect of filtration on circulating leukocytes - I: Change in circulating leukocytes following salvaged blood reinfusion - J: Data collection protocol - K: Raw data - L: References. Leukocyte reducing residual circuit blood after cardiopulmonary bypass has been demonstrated to improve lung function and reduce the inflammatory response after surgery (1). In this study, we examined whether lipid/leuko-rducing cell salvaged blood would improve pulmonary function and reduce the inflammatory response that can develop following the reinfusion of salvaged blood. In addition, all residual circuit blood was transferred to the cell washer at the end of bypass to contribute a significant portion of the final washed product. Fifteen patients undergoing elective cardiac surgery were randomly allocated to a lipid/leuko-reduced group or a control group. In the lipid/leuko-reduced group (n=10) all processed blood was filtered by a lipid globule, C3a, and microaggregate pre-filtered (lipiguard), followed by a leukocyte reducing filter (RC 400). In the control group (n=5) all processed blood was filtered by a 40/150 um dual screen transfusion filter. The lipid/leuko-reduced group showed a significant decrease in pulmonary shunt fraction and an increase in the arterial-venous oxygen difference (p<0.05) following reinfusion, whereas the control group also showed a trend towards decreased pulmonary vascular resistance and a blunting of the leukocytosis that develops following the reinfusion of salvaged blood, although these trends were not statistically significant. The magnitude of rise in circulation red blood cells was equivalent in both groups following reinfusion. These results suggest that lipid/leuko-reducing salvaged blood improves postoperative lung function, is efficacious, and safe for the patient population studied.   Copy/Holding information Location Collection Call No. Status   Walter Schroeder Library Master's Theses AC805 .W43 1997 Available Add Copy to MyList Format: HTMLPlain textDelimited Subject:   Email to:

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