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Item Information   Holdings       More by this author     Pinter, Duane R.     Subjects     Models, Cardiovascular     Computer simulation     Heart, Mechanical     MSP Thesis.     Browse Catalog     by author:      Pinter, Duane R.       by title:      Hardware components ...         MARC Display

Hardware components for an in vitro perfusion simulator / by Duane R. Pinter. by Pinter, Duane R. Subjects Models, Cardiovascular   Computer simulation   Heart, Mechanical   MSP Thesis. Description:  43 leaves : ill. ; 29 cm. Contents:  Clinical advisor: Matthew Hietpas. Committee members: Dr. Vincent Canino, Michael Chier. Introduction -- Materials and methods -- Future improvements -- Discussion. In order to enhance the quality of a perfusionists training, a perfusion simulator is being developed which consists of a PC based system using Visual BasicTM as the programming language, a positive displacement (roller) or vortex (centrifugal) pump, and a mock circulation loop. The perfusion simulator will mimic various physiological responses of the human body during cardiopulmonary abnormal values (i.e. hypertension, hypotension, hyperkalemia, anemia, etc.). This paper will concern itself primarily with the hardware aspect of the simulator. The simulator circuit consists of a modified Donoval circulation loop for arterial and venous pressures and systemic resistances. Either a roller or centrifugal pump can be connected to the circulation loop. Gas flow rate and the O2 mole fraction (sweep and FiO2) is modeled by an electric circuit. The computer has the ability to control the flow, pressure, and resistance of the loop by opening and closing valves. As the characteristics of the circulation loop changes, adjustments made by the perfusionists are detected by the feedback components in the loop. These feedback signals are sent to the computer via a data acquisition board. The signals are analyzed and an algorithm determines the appropriate response to each signal. In order to elicit an appropriate response, data was collected from actual patients to construct a "model" from which the responses can be generated. After the response signal is generated, a control signal is sent to the various mechanical actuators in the circuit. Future improvements to the simulator will consist of adding a total artificial heart or ventricular assist device to the loop, gas transfer equations, an additional tank to simulate metabolism, and the introduction of pharmacological agents.   Copy/Holding information Location Collection Call No. Status   Walter Schroeder Library Master's Theses AC805 .P56 1995 Available Add Copy to MyList Format: HTMLPlain textDelimited Subject:   Email to:

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