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Item Information   Holdings       More by this author     Thompson, Bradley Allen.     Subjects     Cardiopulmonary bypass -- Adverse effects     Extracorporeal Circulation     Hemolysis and hemolysins     MSP Thesis.     Browse Catalog     by author:      Thompson, Bradley Allen.       by title:      The effects of tempe...         MARC Display

The effects of temperature extremes on hemolysis in an extracorporeal circuit / by Bradley Allen Thompson. by Thompson, Bradley Allen. Subjects Cardiopulmonary bypass -- Adverse effects   Extracorporeal Circulation   Hemolysis and hemolysins   MSP Thesis. Description:  i, 26 leaves : ill., charts ; 29 cm. Contents:  Clinical advisor: Mary Jo Bukovic Committee member(s): Dr. Vincent Canino Introduction -- Materials and methods -- Results -- Discussion. Hemolysis is a serious problem that must be improved upon in order to advance cardiopulmonary bypass (CPB) technology. This study was conducted to determine whether extremes could increase or decrease the amount of hemolysis observed in extracorporeal circulation. The temperature extremes were designed to simulate situations that may occur in CPB. The blood of thirteen New Zealand White rabbits was subjected to either profound hypothermia, normothermia, or hyperthermia. The hyperthermia group underwent moderate hypothermia with hyperthermic rewarming. The hypothermia group underwent profound hypothermia and was gradually rewarmed to normothermia at the end of the experiment. The normothermia group remained at normal rabbit core temperature for the entire experiment. Hemolysis was measured by analysis of plasma hemoglobin concentrations over eight hours of circulation. The degree of hemolysis was significantly less in the profound hypothermia group compared to the normothermia and hyperthermia groups. Hemolysis in the hyperthermic group was not statistically different from the normothermic group. Variation of hemolysis between individiual rabbits in the hyperthermic group was greater than either the profound hypothermia or normothermia groups. This data supports the concept that profound hypothermia ( <20°C) protects against RBC trauma whereas hyperthermic rewarming increases the potential for hemolysis in extracorporeal circulation.   Copy/Holding information Location Collection Call No. Status   Walter Schroeder Library Master's Theses AC805 .T466 1996 Available Add Copy to MyList Format: HTMLPlain textDelimited Subject:   Email to:

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