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Item Information   Holdings       More by this author     Mullins, Victor M.     Subjects     Biological control systems -- Mathematical models.     Heart -- Mechanical properties -- Computer simulation     Heart -- Effect of drugs on     Cardiovascular pharmacology     MSP Thesis.     Browse Catalog     by author:      Mullins, Victor M.       by title:      Design and applicati...         MARC Display

Design and application of a pharmacological control module for a perfusion simulator / by Victor M. Mullins. by Mullins, Victor M. Subjects Biological control systems -- Mathematical models.   Heart -- Mechanical properties -- Computer simulation   Heart -- Effect of drugs on   Cardiovascular pharmacology   MSP Thesis. Description:  iv, 86 leaves : Ill. ; 28 cm. Contents:  Clinical advisor: Michael Gough Committee members: Dr. Vincent Canino, Dr. Steven Barnicki, Daniel Minkel Introduction -- Materials & methods -- Results -- Discussion -- References -- Appendix A) Instructions for authors B) List of changes to software code C) Software code added of changed. The Perfusion Simulator being developed at the Milwaukee School of Engineering is comprised of computer software as well as hydraulic and electronic hardware. A cardiopulmonary bypass simulator can be useful to train a perfusion student without an element of risk to a patient. Cardiopulmonary bypass alters the pharmacology of drugs. This is caused by such factors as hypothermia, hemodilution, and contact with the cardiopulmonary bypass apparatus. Much of the changes in pharmacology of drugs while on bypass has not been quantitatively studied. There is a large degree of variability in drug pharmacokinetics and pharmacodynamics among patients during cardiopulmonary bypass as well as among patients in general. Mathematical models were developed to simulate the actions of three drugs which affect the systemic vascular resistance of a patient. The drugs modeled are isoflurane, nitroglycerin, and phenylephrine. For isoflurane, a pharmacodynamic model was used. Both nitroglycerin and phenylephrine were modeled with pharmacokinetic-pharmacodynamic models. After a dose of a specific drug is selected, the resulting effect occurs which in turn interacts with the main module of perfusion software to control a fluid valve which decreases or increases the resistance in the patient model.   Copy/Holding information Location Collection Call No. Status   Walter Schroeder Library Master's Theses AC805 .M85 1996 Available Add Copy to MyList Format: HTMLPlain textDelimited Subject:   Email to:

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