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Item Information   Holdings       More by this author     Dunker, Jerry L.     Subjects     Heart -- Transplantation.     Artificial organs     Heart -- Preservation.     MSP Thesis.     Browse Catalog     by author:      Dunker, Jerry L.       by title:      Proposed autoperfusi...         MARC Display

Proposed autoperfusion technique for donor heart preservation / by Jerry L. Dunker. by Dunker, Jerry L. Subjects Heart -- Transplantation.   Artificial organs   Heart -- Preservation.   MSP Thesis. Description:  22 leaves : ill. ; 29 cm. Contents:  Advisors: Dr. Charles Tritt, Michael Gough, Francis Downey, M.D., Dr. Michael Chier Introduction -- Current preservation techniques and associated problems -- Overcoming current limitations -- Autoperfusion -- Proposed autoperfusion technique -- System components -- Testing -- Investigative plan -- Future considerations. Donor heart availability is the single most limiting factor in heart transplantation today. It is well documented that the safe ischemic time of preserved hearts is currently limited to only 4 to 6 hours. The need for longer periods of preservation is expressed by far more centers than are currently working on this topic. There is also substantial documentation of the problems associated with the current preservation techniques of simple cold storage and microperfusion. These problems, including edema, energy depletion and lack of funcional recovery can all be attributed to ischemia. Autoperfusion is a procedure in which the heart perfuses itself and other various organs outside the body. Autoperfused heart-lung operations offer the advantage of increasing the heart preservation time by eliminating organ ischemia, and allowing continuous functional evaluation of the preserved heart. In autoperfusion preparations in which ony the heart and lungs are used, preservation times have been limited by early pulmonary edema and subsequent deterioration of myocardial function. This led investiagtors to include the kidney, and in some cases the liver, pancreas and duodenum, into the preparation to eliminate excessive water and metabolic wastes. Although this resulted in increased preservation times of up to 37 hours, the probability of having multiple functioning organs from one donor and the logistics of having recipients for all the organs in one center severely restricts this type of procedure. Therefore, this paper proposes a modified technique in which artificial organs are incorporated into existing autoperfusion circuits to provide a preparation that has the potential of extending heart preservation up to 48 hours.   Copy/Holding information Location Collection Call No. Status   Walter Schroeder Library Master's Theses AC805 .D86 1995 Available Add Copy to MyList Format: HTMLPlain textDelimited Subject:   Email to:

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