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Item Information   Holdings       More by this author     Tsarovsky, Gary.     Subjects     Cardiopulmonary bypass -- Adverse effects     Blood Platelets     Hemostasis     Blood Coagulation.     MSP Thesis.     Browse Catalog     by author:      Tsarovsky, Gary.       by title:      Effect of cardiopulm...         MARC Display

Effect of cardiopulmonary bypass duration on platelet function and procoagulant inhibitor systems / by Gary Tsarovsky. by Tsarovsky, Gary. Subjects Cardiopulmonary bypass -- Adverse effects   Blood Platelets   Hemostasis   Blood Coagulation.   MSP Thesis. Description:  vi, 56 leaves : ill., charts ; 29 cm. Contents:  Advisors: Dr. Charles Tritt, Michael Harloff Committee members: Dr. Steven Barnicki, Michael Sanfelippo Introduction -- Purpose -- Background -- Platelet function and CPB -- Procoagulant inhibitor systems -- Antithrombin III -- Protein C and protein S -- Alpha-2-antiplasmin -- Hemostatis defects of CPB and hypothermia -- Materials and methods -- Intraoperative management and data collection -- Hematologic and procoagulant inhibitor system assays -- Statistical analysis -- Results -- Platelet function -- Hematologic and procoagulant inhibitor systems data -- Discussion -- Conclusion -- Appendix A) Instructions for authors - B) Raw data tables - C) Table of normal hematologic values. The purpose of this study was to examine the effect of cardiopulmonary bypass (CPB) duration on platelet function and procoagulant inhibitor systems. The hypothesis tested in this study was that the duration of CPB has a direct correlation with the severity of platelet dysfunction and the activity of the fibrinolytic system of hemostasis Demographic and hematologic data were recorded for 21 patients undergoing elective cardiac surgery. Serial measurements of platelet function, using HemoSTATUS® (HemoTec, Medtronic, Inc., Parker, CO) platelet function test, and activity of procoagulant inhibitor systems were obtained, starting preoperatively and terminating at 24 hours after the operation. A significant decrease in platelet function following termination of CPB and neutralization of heparin (17% decrease from baseline, P < 0.05) was observed, and persisted through the 24-hour postoperative period (11% decrease from baseline). Correlation between CPB time and 24-hour chest tube drainage was present ( r = 0.402, P = NS). Correlation between procoagulant inhibitor systems and CTD existed and was significant for protein C (r = 0.525, P = 0.0277) and protein S (r = 0.486, P = 0.409) at the time of heparin reversal. Correlations between CPB duration and activity of procoagulant inhibitor systems, CPB duration and platelet function, as well as platelet function and activity of procoagulant inhibitor systems existed, but were not statistically significant. The data obtained in this study does not demonstrate a statistically significant correlation between duration of CPB and platelet function. Platelet function, as assessed by HemoSTATUS platelet function test, and activity of procoagulant inhibitor systems may be useful in the observing trends in patient’s perioperative hemostasis, but, based on the data collected in this study, do not definitively identify patients at risk of excessive postoperative blood loss.   Copy/Holding information Location Collection Call No. Status   Walter Schroeder Library Master's Theses AC805 .T73 1998 Available Add Copy to MyList Format: HTMLPlain textDelimited Subject:   Email to:

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