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Item Information   Holdings       More by this author     Hummel, Richard T.     Subjects     Heparin     Cardiopulmonary bypass -- Adverse effects     Heart, Mechanical     Inflammation     MSP Thesis.     Browse Catalog     by author:      Hummel, Richard T.       by title:      In vitro comparison ...         MARC Display

In vitro comparison of Carmeda® and Duraflo® II heparin bonded circuits / by Richard T. Hummel. by Hummel, Richard T. Subjects Heparin   Cardiopulmonary bypass -- Adverse effects   Heart, Mechanical   Inflammation   MSP Thesis. Description:  45 leaves : ill., charts ; 29 cm. Contents:  Advisor: Charles Altenbern Committee members: Dr. Cynthia Barnicki, Dr. Charles Tritt, Alfred Tector, M.D. Introduction -- Materials and methods -- Results -- Discussion. The purpose of this experiment is to compare two different heparin coated cardiopulmonary bypass (CPB) circuits which are both commonly utilized during thoracic operations. Duraflo® II ( Baxter-Bentley® Healthcare Corp.) is composed of ionically bound heparin, while the Carmeda® BioActive Surface (Medtronic Inc.) has heparin covalently bound to a prepared surface resulting in end-point attachment. The combination of elevated activated clotting time (ACT), activated partial thromboplastin time (aPTT), and protamine titration in the Duraflo circuits indicate that heparin is immediately released from the blood contact surface upon initiation of extracorporeal circulation (ECC) and continues to be liberated throughout the circulation time. Increased plasma free hemoglobin levels in the Duraflo coated circuits indicated that they may also be less blood-compatible then Carmeda circuits. The loss of helparin from the blood contact surface likely has some effect on this difference although it can not be proven from this study whether this was the main determinant. Some of the hemolysis could be due to shear stresses exerted on the blood within the individual components which would be a result of product design. Nevertheless, the covalently bound Carmeda circuits retain their heparin coating more efficiently and thus may offer more benefits in the long run.   Copy/Holding information Location Collection Call No. Status   Walter Schroeder Library Master's Theses AC805 .H86 1995 Available Add Copy to MyList Format: HTMLPlain textDelimited Subject:   Email to:

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