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Item Information   Holdings       More by this author     Robertson, Michael, author.     Milwaukee School of Engineering     Subjects     Magnesium     Cardiopulmonary bypass -- Adverse effects     Blood -- Filtration     Ultrafiltration.     Anticoagulants -- therapeutic use.     MSP Thesis.     Browse Catalog     by author:      Robertson, Michael, author.      Milwaukee School of Engineering       by title:      The effect of magnes...         MARC Display

The effect of magnesium on anticoagulation for cardiopulmonary bypass : a thesis submitted to the faculty of the Milwaukee School of Engineering in partial fulfillment of the requirements for the degree of Master of Science in Perfusion / by Michael Robertson. by Robertson, Michael, author., Milwaukee School of Engineering Subjects Magnesium   Cardiopulmonary bypass -- Adverse effects   Blood -- Filtration   Ultrafiltration.   Anticoagulants -- therapeutic use.   MSP Thesis. Description:  30 leaves : illustrations ; 29 cm. Contents:  Introduction -- Background -- Methods -- Results -- Discussion -- Conclusion. During the use of cardiopulmonary bypass (CPB), the use of ultrafiltration is often necessary. Ultrafiltration is a process that filters the blood via a hemoconcentrator for a variety of reasons. During this process, there is a risk of blood components being removed from the blood which can become deficient if not accounted for. These components include drugs, electrolytes, and proteins. Schilling, in a thesis completed at the Milwaukee School of Engineering (MSOE), proposed that the removal of magnesium during ultrafiltration might interfere with blood clotting. The goal of this study was to further investigate whether magnesium concentration of highly filtered blood would affect coagulation. Bovine blood was used to prime a CPB circuit that was used to filter the blood as a means of removing magnesium. As the blood was filtered, 0.9% saline was added back to maintain the overall volume. Baseline activated clotting times (ACTs) were run prior to the filtration at multiple heparin doses in an attempt to construct a heparin dose response curve. After the filtration, magnesium was then added back into the circuit in small amounts, and ACT values were recorded after each additional amount of magnesium was added. The ACT after the filtration was nearly equal to the baseline ACT, suggesting that large volumes of ultrafiltration had no effect on the ACT. However, when magnesium was added back into the circuit, the ACTs then dropped. Unfortunately, due to the unexpected heparin response of the bovine blood, adequate anticoagulation was not achieved and the circuit clotted off before all data points were reached. After significant clot was formed, ACTs then rose likely due to the consumption of clotting factors in a given volume of blood. This study demonstrated that excessive ultrafiltration had little effect on the ACT relative to baseline. However, magnesium was found to facilitate hemostasis when added back into the circuit in physiological amounts. Form:  text unmediated volume   Copy/Holding information Location Collection Call No. Status   Walter Schroeder Library Master's Theses AC805 .R61 2015 Available Add Copy to MyList Format: HTMLPlain textDelimited Subject:   Email to:

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