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Walter Schroeder Library, Milwaukee School of Engineering
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Preston, James D., author.
Milwaukee School of Engineering
Subjects
Aorta -- Surgery.
Heart failure -- Treatment
Cardiovascular system
Simulation methods
Parameter estimation
MSCS Thesis.
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Preston, James D., author.
Milwaukee School of Engineering
by title:
Lumped parameter mod...
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Lumped parameter modeling of the human aorta during aortomyoplasty treatment : a thesis submitted to the faculty of the Milwaukee School of Engineering in partial fulfillment of the requirements for the degree of Master of Science in Cardiovascular Studies / by James D. Preston.
by
Preston, James D., author.
, Milwaukee School of Engineering
Subjects
Aorta -- Surgery.
Heart failure -- Treatment
Cardiovascular system
Simulation methods
Parameter estimation
MSCS Thesis.
Description:
76 leaves : illustrations, some of which are in color ; 29 cm.
Contents:
Introduction -- Background -- Methods -- Results and discussion -- Conclusions and recommendations - References -- Appendix A: MainProgram.m -- B: ModelParameters.m -- C: ModelSolver.m.
The objective of this thesis is to report the results of a project entailing the design and testing of a mathematical model of the human aortic tree undergoing aortomyoplasty (AMP) treatment. AMP is a potential treatment for terminal heart failure, which produces a counterpulsation effect similar to that of the intra-aortic balloon pump (IABP). In AMP, skeletal muscle is wrapped around the outside of the patient's aorta, and paced to contract in a rhythm of counterpulsation with the heart. The skeletal muscle squeezes the walls of the aorta inward, producing an occlusion effect similar to the inflation of the IABP.
This model was adapted from an earlier work by Richard Hillestad, wherein the aorta was modeled as a lumped parameter electrical system of resistance, inductance, and capacitance. In Hillestad's paper, the electrical model of the aorta was constructed using physical electrical components, and the simulations consisted of running an electric current through the system and measuring the outputs.
The methods described in this thesis continued the work started by Hillestad. In this thesis, the ordinary differential state equations were derived for the lumped parameter model. These state equations were then encoded into a configurable set of routines in MATLAB. The MATLAB code is configurable, in that the researcher can easily vary several key components of the model, including the input pressure waveform; the resistance, compliance, and inertance; and the location and timing of the AMP treatment.
The results described in this thesis are promising. The state equations derived for the model produced similar results to the electric circuit built by Hillestad. The MATLAB routines also demonstrated the viability of this model to be configured for a variety of purposes. In addition, the modeling of AMP treatment was shown to be feasible using the framework of this model. More work will need to be done to ensure the accuracy of this model as an approximation of AMP treatment.
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Walter Schroeder Library
Master's Theses
AC805 .P74 2015
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