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Item Information   Holdings       More by this author     Herrmann, Katelyn. [author].     Milwaukee School of Engineering     Subjects     Donor organ shortage     Heart -- Transplantation.     Heart -- Preservation.     Tissue and Organ Procurement.     Non-heart beating organ donation -- Law and legislation     MSP Thesis.     Browse Catalog     by author:      Herrmann, Katelyn. [author].      Milwaukee School of Engineering       by title:      Improving the viabil...         MARC Display

Improving the viability of donor hearts for transplant : Design and evaluation of a circuit to perfuse an isolated rat heart : a thesis submitted to the faculty of the Milwaukee School of Engineering in partial fulfillment of the requirements for the degree of Master of Science in Perfusion / by Katelyn Herrmann. by Herrmann, Katelyn. [author]., Milwaukee School of Engineering Subjects Donor organ shortage   Heart -- Transplantation.   Heart -- Preservation.   Tissue and Organ Procurement.   Non-heart beating organ donation -- Law and legislation   MSP Thesis. Description:  66 leaves : illustrations, some of which are in color ; 29 cm. Contents:  Introduction -- Background -- Overview of experimental methods -- Ex-vivo perfusion system: materials, methods, and design -- Experimental results and analysis -- Discussion -- Conclusion and recommendations -- Appendix A: Product information for the Terumo CDI 500 -- B: Product information for the Terumo RX05 Oxygenator -- C: Product information for the Maquet Quadrox-iD Pediatric Oxygenator -- D: Photographs of the EVHP System. The field of heart transplantation faces many challenges, but few are as substantial as the large discrepancy between the supply and demand of donor hearts. Due to the shortage of available organs, patients in need of a heart transplant face a high risk of waitlist mortality. The research described in this document is intended to address this issue by investigating the use of extended criteria donors. A proof of concept study was designed to investigate the potential for using a custom designed asanguineous solution and ex-vivo perfusion circuit to preserve and recondition hearts that otherwise do not meet donation criteria to restore them to normal, viable function -- thus expanding the donor pool. The purpose of this project specifically was to design and operate, according to given specifications, a circuit to perfuse an isolated rat heart. To date, the designed circuit has been successfully used to perfuse a total of five isolated rat hearts. While the proof of concept study remains in its early phase, preliminary results are promising as the hearts exposed to six hours of ex-vivo perfusion with the custom solution show minimal signs of irreversible cellular injury. Form:  text unmediated volume   Copy/Holding information Location Collection Call No. Status   Walter Schroeder Library Master's Theses AC805 .H466 2015 Available Add Copy to MyList Format: HTMLPlain textDelimited Subject:   Email to:

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