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Item Information   Holdings       More by this author     Axarlis, AnnMarie.     Subjects     Adenosine triphosphate -- Physiological effect.     Cardiac arrest, Induced     Cardiopulmonary bypass     MSP Thesis.     Browse Catalog     by author:      Axarlis, AnnMarie.       by title:      A retrospective anal...         MARC Display

A retrospective analysis of the clinical benefits of adenosine enhanced cardioplegia / by AnnMarie Axarlis. by Axarlis, AnnMarie. Subjects Adenosine triphosphate -- Physiological effect.   Cardiac arrest, Induced   Cardiopulmonary bypass   MSP Thesis. Description:  44 leaves : ill. ; 29 cm. Contents:  Thesis advisor: Dr. Ronald Gerrits. Committee members: Dr. Larry Fennigkoh, Shannon Vorborsky. Introduction -- Background -- Methods -- Results -- Discussion -- Conclusions and recommendations -- Appendix A: Statistical calculations. The goal of this study was to determine if adding adenosine to the cardioplegia used during cardiopulmonary bypass provided post-surgical benefit to the heart by improving cardiac function. This study was performed retrospectively using patient charts from a single surgeon in which some patients did not receive adenosine in the cardioplegia (control group, n=21) while others did (adenosine group, n=21). The patient charts were examined for the number of inotropes used and their individual infusion doses, as well as the pre-operative, post-operative, and follow up ejection fractions estimated by echocardiography. The results of the inotrope study indicated a non-significant difference in the number of inotrope (p=0.052) and the infusion dose of inotropes (p=0.119) between the adenosine and control group as determined by t-tests and Mann-Whitney tests. Unpaired t-tests were performed for each time point the ejection fraction was estimated from echocardiographys, which was pre-operatively, post-operatively, and a surgical follow up. There was no difference in ejection fractions between the adenosine and control groups as determined in the pre-operative (p=0.421) and post-operative groups (p=0.690). However, the follow up ejection fraction unpaired t-test revealed a significant difference between the control and adenosine group (p=0.045). The results of this study indicated adenosine cardioplegia offers no myocardial protection for this protocol in terms of a decreased need for inotrope support post-operatively, but the study indicated improved ejection fraction in a follow up echocardiography 2-8 months post-operatively. However, the results should be interpreted carefully as the sample sizes in each group were very small, such that this study may not have had the power to determine clinical differences.   Copy/Holding information Location Collection Call No. Status   Walter Schroeder Library Master's Theses AC805 .A99 2013 Available Add Copy to MyList Format: HTMLPlain textDelimited Subject:   Email to:

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