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Item Information   Holdings       More by this author     Richman, Adam.     Subjects     Extracorporeal membrane oxygenation.     Blood -- Circulation, Artificial     Oxygen -- Physiological transport     Adults -- Respiratory system -- Therapy.     Children -- Respiratory system -- Therapy.     MSP Thesis.     Browse Catalog     by author:      Richman, Adam.       by title:      The effects of flow ...         MARC Display

The effects of flow rate on mixed venous oxygen content and saturation in veno-venous extracorporeal life support : a comparison of a computer simulation and an in vitro analysis / by Adam Richman. by Richman, Adam. Subjects Extracorporeal membrane oxygenation.   Blood -- Circulation, Artificial   Oxygen -- Physiological transport   Adults -- Respiratory system -- Therapy.   Children -- Respiratory system -- Therapy.   MSP Thesis. Description:  72 leaves : ill. ; 29 cm. Contents:  Thesis advisor: Dr. Jeffrey LaMack. Committee members: Dr. Charles Tritt, Matt Hietpas. Introduction -- Background -- Materials and methods -- Results -- Discussion -- Conclusion -- A: Raw data -- B: Statistical output from Minitab testing -- C: MATLAB code for VVECLS03112012.m (Main GUI) -- D: MATLAB code for calcpo2.m (Function called by GUI). Extracorporeal life support (ECLS) is the extended use of cardiopulmonary bypass (CPB) to support patients suffering from reversible cardiac and/or respiratory failure. Veno-venous ECLS (VV ECLS) is used to support patients suffering from only respiratory failure. Because the drainage and reinfusion cannulae for VV ECLS are both located in the venous circulation, a phenomenon known as recirculation occurs where oxygenated blood will be drained out again and recirculated through the ECLS circuit. This study compared a MATLAB simulation of recirculation with an experiment to characterize the relationship between ECLS drainage blood oxygen content and recirculation. A MATLAB graphical user interface (GUI) was created which accepts user-specified values for saturation (SO2) and partial pressure of oxygen (PO2) for oxygenated and deoxygenated blood, as well as hemoglobin concentration, recirculation fraction, and the pH of the drainage blood. This model then predicts, based on conservation equations, the oxygen content and saturation of ECLS drainage blood. Two in vitro CPB circuits were also constructed, one for oxygenation and one for deoxygenation. The blood was then mixed in different proportions to simulate different levels of recirculation, and the oxygen content and saturation were measured and compared to model predictions. The results illustrate that a linear relationship exists between recirculation fraction and ECLS drainage blood oxygen content (p < 0.001), and that the MATLAB model is a very accurate predictor of ECLS drainage blood oxygen content and saturation, based on comparison to experimental data. It was also determined that hemoglobin concentration and pH of the drainage blood can have a dramatic effect on the ECLS drainage blood oxygen content and saturation, respectively. web address:  https://msoe.tind.io/record/961   Copy/Holding information Location Collection Call No. Status   Walter Schroeder Library Master's Theses AC805 .R504 2012 Available Add Copy to MyList Format: HTMLPlain textDelimited Subject:   Email to:

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