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Item Information   Holdings       More by this author     Tucker, Sherrelle     Subjects     Centrifugal pumps     Embolism     Blood -- Circulation, Artificial -- Complications.     Cavitation     Inflammation     Tissue respiration     Necrosis     MSP Thesis.     Browse Catalog     by author:      Tucker, Sherrelle       by title:      The effect of clampi...         MARC Display

The effect of clamping the outlet of a centrifugal pump on gaseous microemboli production / by Sherrelle Tucker. by Tucker, Sherrelle Subjects Centrifugal pumps   Embolism   Blood -- Circulation, Artificial -- Complications.   Cavitation   Inflammation   Tissue respiration   Necrosis   MSP Thesis. Description:  58 leaves : ill. ; 29 cm. Contents:  Thesis advisor: Dr. Ronald Gerrits Committee members: Dr. Larry Fennigkoh, Kirsten Kallies. Background -- Methods -- Results -- Discussion -- Future recommendations -- A: Raw data -- B: Full statistical analysis. Clamping the outlet of a running centrifugal pump is common practice, and generally considered safe by perfusionists. Gaseous microemboli (GME) production caused by clamping the inlet of a centrifugal pump is well documented. Yet no experiments studying the effect of clamping the outlet of a centrifugal pump on GME production have been carried out. The purpose of this experiment was to investigate if outlet clamp time or speed of the running centrifugal pump during clamping affects GME production. Total GME count and air volume were measured while varying clamp time and pump speed. an EDACTM QUANTIFIER sensor manufactured by Luna Innovations, Inc. was placed in the outlet of the centrifugal pump to measure both the number of GME and their combined total volume of aid (μL). Results indicate that both clamp time and pump speed had a statistically significant effect on total GME count and air volume (P<0.05). In this experiment, longer clamp time produced more total GME and overall air volume. Additionally, as pump speed increased while the outlet was clamped, more total GME and air volume were measured. The results of this study suggest that clamping the outlet of the pump for at least 5 minutes will have an effect on air production in a cardiopulmonary bypass (CPB) circuit. Internal recirculation cavitation caused by increased pump head turbulence and heat generation in the pump head may be the cause of the air production.   Copy/Holding information Location Collection Call No. Status   Walter Schroeder Library Master's Theses AC805 .T83 2012 Available Add Copy to MyList Format: HTMLPlain textDelimited Subject:   Email to:

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